[Influence of paternal age].

Father's age increase miscarriage, malformation, risk of autism, schizophrenia, and bipolar troubles in children.

[Effects of micronized natural progesterone on the liver during the third trimester of pregnancy].

In France, prescription of micronized progesterone at high doses of 900 to 1200 mg/day is common practice in the case of preterm delivery, even though this is neither an indication nor a posology given for marketing authorisation. A few cases of gestational pruritus have been reported during such use, associated with cholestasic and/or cytolytic hepatic disorders. We report here the results of a controlled, double-blind study versus a placebo, aimed at assessing the effects on the liver of micronized progesterone administered orally at high doses (900-1200 mg/day), conducted in a population of 201 women presenting moderate menace of preterm delivery during the third trimester of pregnancy.

[Endoscopic laser CO2 treatment of infertility due to polycystic ovarian syndrome].

In a prospective study, 30 women with polycystic ovarian disease resistant to clomiphene citrate therapy and gonadotropins were treated success fully with laparoscopic ovarian CO2 laser vaporization or CO2 laser wedge resection.

[Tumor necrosis factor and induced labor].

TNF and LPS can induced labour in mice. In our serial, in induced RU 486 labour, TNF value enhanced 48 hours after RU 486 and decreased after parturition.

[Uterine rupture during labor following surgical hysteroscopy].

Two cases of obstetrical uterine rupture after operative hysteroscopy without perforation are described. One was treated for uterus septus, the other one for synechia. However, the uterus could have been fragilized in both cases: one had been perforated by a uterine device, the other case had a past history of repeated curetage.