The Dynamics, Degradation, and Afterlives of Pectins: Influences on Cell Wall Assembly and Structure, Plant Development and Physiology, Agronomy, and Biotechnology.

Pectins underpin the assembly, molecular architecture, and physical properties of plant cell walls and through their effects on cell growth and adhesion influence many aspects of plant development. They are some of the most dynamic components of plant cell walls, and pectin remodeling and degradation by pectin-modifying enzymes can drive developmental programming via physical effects on the cell wall and the generation of oligosaccharides that can act as signaling ligands. Here, we introduce pectin structure and synthesis and discuss pectin functions in plants.

Do you think medicines can be prescribed in a more eco-directed, greener way? A qualitative study based on public and prescriber focus groups on the impact of pharmaceuticals in Scotland's water environment.

Objectives: This qualitative study explored public and prescriber awareness of pharmaceutical pollution in the water environment and eco-directed sustainable prescribing (EDSP) as a mitigation strategy to reduce the environmental impact of prescribing in Scotland.

Design: Focus groups explored prescriber and public perceptions of the topic. Common questions were asked through semistructured facilitation.

Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function.

Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and termination. Although the function of hypusinated eIF5A (eIF5A) in cellular proliferation is well-characterized, the role of its unhypusinated form (eIF5A) remains unclear. We hypothesized that eIF5A exerts independent, negative effects on cellular replication and metabolism, distinct from the loss of eIF5A.

Current Practices and Perspectives of Artificial Intelligence in the Clinical Management of Eating Disorders: Insights From Clinicians and Community Participants.

Objective: Artificial intelligence (AI) could revolutionize the delivery of mental health care, helping to streamline clinician workflows and assist with diagnostic and treatment decisions. Yet, before AI can be integrated into practice, it is necessary to understand perspectives of these tools to inform facilitators and barriers to their uptake. We gathered data on clinician and community participant perspectives of incorporating AI in the clinical management of eating disorders.

Robust near-infrared modeling for pharmaceutical powder streams: External variable augmented iterative optimization technology (EVA-IOT).

The adoption of pure component models, such as iterative optimization technology (IOT) algorithms, is gaining significant interest in the pharmaceutical industry, primarily because of their calibration-free/minimal calibration requirements for process analytical technology applications. The IOT methods have recently demonstrated great potential for monitoring the quality of continuous powder mixtures by Near-infrared (NIR) spectroscopy. However, the dynamic conditions of continuous manufacturing processes may limit the effectiveness of such approaches.