Publications by authors named "C Le Stradic"
Objectives: SARS-CoV-2 induces a broad spectrum of clinical manifestations, which overlap with other viral infections very common in children. We aimed to describe the percentage of positive SARS-CoV-2 RT-PCR tests in symptomatic and asymptomatic ambulatory children and to determine the predictive factors for positivity.
Patients And Methods: From June 1 to July 31, 2020, we conducted a cross-sectional prospective, multicenter study (13 hospital emergency units and 59 ambulatory pediatricians) throughout France.
Article Synopsis
- - The study analyzed 126 individuals from 64 families with hereditary xerocytosis, revealing various clinical, hematologic, and genetic characteristics including specific mutations like p.Arg352His and new probable pathogenic variations.
- - Key symptoms for diagnosis included persistent hemolysis after spleen removal and increased ferritin levels, along with significant risk factors for thrombotic events post-splenectomy and severe anemia in related disorders, which differ from hereditary xerocytosis.
- - Findings highlight that hereditary xerocytosis and Gardos channelopathy are distinct conditions with shared features like hemolysis and iron overload, emphasizing the need for improved diagnosis and management strategies for affected patients.
Introduction: Duodenal duplications are rare congenital malformations whose revealing signs are highly variable and nonspecific.
Observation: We report the case of a female infant who presented with neonatal acute pancreatitis complicated by recurrent ascites, profound hypoalbuminemia responsible for pleural and pericardial effusions, revealing a duodenal duplication cyst. The unusual and original clinical presentation as well as the difficulty detecting the duplication radiologically delayed the diagnosis.
Tocilizumab (TCZ) is an anti-interleukin-6-receptor antibody. The blockade of IL-6 is used as a strategy for the treatment of systemic juvenile idiopathic arthritis (S-JIA) and multicentric Castleman disease (MCD). In this study, we describe the tolerability profile of tocilizumab in eight children followed in a pediatric rheumatology department.
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