Detection of genes with differential expression dispersion unravels the role of autophagy in cancer progression.

The majority of gene expression studies focus on the search for genes whose mean expression is different between two or more populations of samples in the so-called "differential expression analysis" approach. However, a difference in variance in gene expression may also be biologically and physiologically relevant. In the classical statistical model used to analyze RNA-sequencing (RNA-seq) data, the dispersion, which defines the variance, is only considered as a parameter to be estimated prior to identifying a difference in mean expression between conditions of interest.

Spatial Clustering of Depinning Avalanches in Presence of Long-Range Interactions.

Disordered elastic interfaces display avalanche dynamics at the depinning transition. For short-range interactions, avalanches correspond to compact reorganizations of the interface well described by the depinning theory. For long-range elasticity, an avalanche is a collection of spatially disconnected clusters.

Universal Scaling of the Velocity Field in Crack Front Propagation.

The propagation of a crack front in disordered materials is jerky and characterized by bursts of activity, called avalanches. These phenomena are the manifestation of an out-of-equilibrium phase transition originated by the disorder. As a result avalanches display universal scalings which are, however, difficult to characterize in experiments at a finite drive.

Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa.

Genetic determinants of antibiotic resistance (AR) have been extensively investigated. High-throughput sequencing allows for the assessment of the relationship between genotype and phenotype. A panel of 672 Pseudomonas aeruginosa strains was analysed, including representatives of globally disseminated multidrug-resistant and extensively drug-resistant clones; genomes and multiple antibiograms were available.

Geometrical dependence of quantum decoherence in circular arenas with side-wires.

Low-temperature quantum phase coherence lengths were experimentally measured in mesoscopic circular arenas fabricated on InGaAs quantum wells. The arenas are connected to wide sample regions by short side-wires, to investigate the effects of geometry in comparison to intrinsic materials properties on quantum decoherence. Universal conductance fluctuations were used to quantify the phase coherence lengths as a function of temperature and geometry.