Publications by authors named "C Le Morvan"
Enteroviruses (EV) initiate replication by binding to their cellular receptors, leading to the uncoating and release of the viral genome into the cytosol of the host cell. Neutralising antibodies (NAbs) binding to epitopes on enteroviral capsid proteins can inhibit this infectious process through several mechanisms of neutralisation in vitro. Fc-mediated antibody effector functions such as antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis have also been described for some EV.
View Article and Find Full Text PDFAdaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota.
NPJ Biofilms Microbiomes
September 2024
Article Synopsis
- * Research investigated how bacteria might develop resistance to AF, focusing on the role of the thioredoxin reductase enzyme (TrxB) and its multiple forms in clinical strains, though the number of TrxB genes didn't affect AF's minimum inhibitory concentration (MIC).
- * Mutations that arose after long-term exposure to AF were found in an anti-sigma factor, impacting bacterial physiology, and AF was shown to have a lesser effect on human gut microbiota compared to the antibiotic vancomycin.
Unlabelled: , the major cause of antibiotic-associated diarrhea, is a strict anaerobic, sporulating Firmicutes. However, during its infectious cycle, this anaerobe is exposed to low oxygen (O) tensions, with a longitudinal decreasing gradient along the gastrointestinal tract and a second lateral gradient with higher O tensions in the vicinity of the cells. A plethora of enzymes involved in oxidative stress detoxication has been identified in , including four O-reducing enzymes: two flavodiiron proteins (FdpA and FdpF) and two reverse rubrerythrins (revRbr1 and revRbr2).
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- Intestinal inflammation alters the composition and metabolism of gut microbiota, but the host's response to these changes is not fully understood.* -
- Mucosal-associated invariant T (MAIT) cells can detect metabolites from riboflavin-producing bacteria that increase during inflammation, promoting tissue repair in the intestines.* -
- Mice without MAIT cells showed higher susceptibility to colitis and related colorectal cancer, highlighting the significance of MAIT cells in responding to gut inflammation through bacterial metabolic pathways.*
The thioredoxin (Trx) system, found universally, is responsible for the regeneration of reversibly oxidized protein thiols in living cells. This system is made up of a Trx and a Trx reductase, and it plays a central role in maintaining thiol-based redox homeostasis by reducing oxidized protein thiols, such as disulfide bonds in proteins. Some Trxs also possess a chaperone function that is independent of thiol-disulfide exchange, in addition to their thiol-disulfide reductase activity.
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