Publications by authors named "C Le Dantec"
Article Synopsis
- Systemic sclerosis (SSc) is a complicated disease with various manifestations, making it hard to manage, but autoantibodies may help identify different patient groups and their underlying mechanisms.
- A study of 206 SSc patients used antibody status (ACA and SCL70) and various biological analyses to explore differences between groups.
- Results showed that SCL70-positive patients had more severe symptoms and unique biological profiles, while ACA-positive patients had a different set of immune and metabolic features, highlighting the importance of serological status in understanding and treating the disease.
The conventional classification of mature B cells overlooks the diversity within IgD CD27 naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RB B cells (NA RB-) and CD45RB B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM.
View Article and Find Full Text PDFPrecise regulation of B cell differentiation is essential for an effective adaptive immune response. Here, we show that B cell development in mice with B cell-specific Maf deletion is unaffected, but marginal zone B cells, germinal centre B cells, and plasmablasts are significantly more frequent in the spleen of naive Maf-deficient mice compared to wild type controls. In the context of a T cell-dependent immunization, Maf deletion causes increased proliferation of germinal centre B cells and extrafollicular plasmablasts.
View Article and Find Full Text PDFObjective: While the involvement of IL-7/IL-7R axis in pSS has been described in relation to T cells, little is known about the contribution of this pathway in relationship with other immune cells, and its implication in autoimmunity. Using high-content multiomics data, we aimed at characterizing IL-7R expressing cells and the involvement of IL-7/IL-7R pathway in pSS pathophysiology.
Methods: An IL-7 signature established using RNA-sequencing of human PBMCs incubated with IL-7 was applied to 304 pSS patients, and on RNA-Seq datasets from tissue biopsies.
Article Synopsis
- Persistent inflammation can lead to the formation of tertiary lymphoid structures (TLS) that resemble secondary lymphoid organs (SLO) like lymph nodes, with variations in TLS composition linked to different diseases.
- Researchers conducted an analysis of colorectal and gastric tissues from patients with various inflammatory diseases and cancers, utilizing imaging mass cytometry (IMC) to compare TLS and SLO based on 39 specific markers.
- The study found that while TLS organization varies among patients, it follows a maturation spectrum categorized into three stages: lymphoid-aggregates, non-GC TLS, and GC-like TLS, revealing insights into the architectural and functional differences that can have implications for diagnostic and prognostic assessments in diseases.