Publications by authors named "C Laughlin"
Article Synopsis
- Monocytes and macrophages are critical for defending the body but also play a role in inflammation-related diseases, complicating their study.
- Researchers identified the Fth1 gene, linked to ferritin H chain production, as a key indicator of alveolar macrophage activity during lung inflammation, using a specialized Fth1-mScarlet reporter mouse to monitor this process.
- The Fth1 marker showed increased activity in monocytes during inflammation and helped distinguish between different immune cell types, potentially improving our understanding of macrophage responses and differentiation in inflammatory conditions.
Background: Healthy Lifetime, a theoretically driven, personalized health coaching program delivered electronically, including face-to-face videoconferencing, was developed to intervene in early aging to stave off functional decline and minimize the onset/exacerbation of chronic conditions.
Objective: To determine the efficacy of a theoretically driven, personalized health coaching program in participants 50 years and older with one or more chronic conditions using a randomized, controlled, pragmatic clinical trial methodology.
Methods: Participants were randomly assigned to the HL (n = 59) or a usual care (n = 63) group.
Social determinants of health are the conditions in the environment that influence health outcomes, such as housing, transportation, and neighborhoods. In this report, we examine 3 cases of participants with social risk factors who participated in a health coaching intervention study. The study was a science-based, nurse health coaching model provided to older adult participants in a Midwestern state designed to equip and empower them to achieve and maintain their health and optimum function to support independent living at home.
View Article and Find Full Text PDFPolygenic contributions to performance on the Balloon Analogue Risk Task.
Mol Psychiatry
August 2023
Risky decision-making is a common, heritable endophenotype seen across many psychiatric disorders. Its underlying genetic architecture is incompletely explored. We examined behavior in the Balloon Analogue Risk Task (BART), which tests risky decision-making, in two independent samples of European ancestry.
View Article and Find Full Text PDFArticle Synopsis
- Emerging research highlights that the gut microbiome can influence tumor immunity and how well cancer treatments work, especially in melanoma.
- The study focuses on developing a culturomics method to recover various live bacteria from tumors that are not directly located in the gut, despite their low presence.
- It outlines specific procedures for preparing media, isolating tissues, and conducting cultures, along with sequencing techniques for detailed analysis.