Publications by authors named "C Lauer"
Unlabelled: Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 CD4-binding site (CD4bs) occur infrequently in macaques and humans and have not been reproducibly elicited in any outbred animal model. To address this challenge, we first isolated RHA10, an infection-induced rhesus bNAb with 51% breadth. The cryo-EM structure of RHA10 with HIV-1 envelope (Env) resembled prototypic human CD4bs bNAbs with CDR-H3-dominated binding.
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- The study examined the impact of transitioning to an Acute Care Surgery (ACS) model at a community hospital on Emergency General Surgery (EGS) patients, focusing on access to care and mortality rates.
- It analyzed data from 467 patients before the transition and 238 patients after, noting an increase in older, Black, and underinsured patients post-transition, but no significant changes in mortality rates or hospital stay length.
- However, there was a notable increase in hospital readmissions after the transition, suggesting that while access improved, the quality of care necessitates further examination.
Objectives: Acute Care Surgery (ACS) admissions and procedures are substantially increasing. ACS disproportionally accounts for a majority of morbidity and mortality among surgical patients. Minimally invasive techniques are associated with improved outcomes and shorter hospital length of stay within the ACS population.
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- The study outlines a 10-year quality improvement program for surgical stabilization of rib fractures (SSRF) at a Level 1 trauma center to improve patient outcomes and ensure safety.
- The research involved a review of cases from 2022, focusing on various data points like patient demographics, complications, and rib fracture specifics for 82 identified patients, where 88% underwent SSRF.
- Results indicated that SSRF patients had a 15% mortality rate, with notable complications linked to factors like the number of ribs stabilized and trauma severity, emphasizing the need for ongoing scrutiny in surgical practices.*
We present a calibration scheme to determine the conversion factors from a coarse-grained stochastic approximation Monte Carlo approach using the PRIME20 peptide interaction model to atomistic force-field interaction energies at full explicit aqueous solvation. The conversion from coarse-grained to atomistic structures was performed according to our previously established inverse coarse-graining protocol. We provide a physical energy scale for both the backbone hydrogen bonding interactions and the sidechain interactions by correlating the dimensionless energy descriptors of the PRIME20 model with the energies averaged over molecular dynamics simulations.
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