Publications by authors named "C Laudanna"
Background: Immune cell metabolism governs the outcome of immune responses and contributes to the development of autoimmunity by controlling lymphocyte pathogenic potential. In this study, we evaluated the metabolic profile of myelin-specific murine encephalitogenic T cells, to identify novel therapeutic targets for autoimmune neuroinflammation.
Methods: We performed metabolomics analysis on actively-proliferating encephalitogenic T cells to study their overall metabolic profile in comparison to resting T cells.
Article Synopsis
- Richter's syndrome (RS) is a severe form of cancer resulting from the evolution of chronic lymphocytic leukemia (CLL) into a high-grade B-cell malignancy, characterized by decreased reliance on BCL-2, a key protein that prevents apoptosis (cell death).
- Studies comparing CLL and RS revealed that RS cells display lower apoptotic priming and may depend on different anti-apoptotic proteins, complicating treatment strategies like using BH3 mimetics that target cell death pathways.
- Transcriptomic analyses showed that as CLL transforms into RS, there is a downregulation of pro-apoptotic factors and changes in mitochondrial structure that contribute to enhanced resistance to apoptosis, making it harder to target RS directly.
In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs.
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- Mutation-targeted therapy for cystic fibrosis (CF) is not suitable for all patients, particularly those with rare CFTR gene variants like W57G/A234D.
- Researchers analyzed how these variants affect CFTR protein stability using colonoids and nasal epithelial cells, utilizing methods like western blotting and Ussing chamber analysis.
- Treatment with CFTR modulators (VX661, VX445, VX770) showed improved CFTR function, reduced sweat chloride levels, and an increase in lung function (FEV1%) after 27 weeks, highlighting the importance of personalized treatment approaches for CF.