Sensitivity of pollutant concentrations in urban streets to asphalt and traffic-related emissions.

The higher concentrations of atmospheric particles, such as black carbon (BC) and organic matter (OM), detected in streets compared to the urban background are predominantly attributed to road traffic. The integration of this source of pollutant in air quality models nevertheless entails a high degree of uncertainty and some other sources may be missing. Through sensitivity scenarios, the impacts on pollutant concentrations of sensitivities related to traffic and road-asphalt emissions are evaluated.

Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.

Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its altered metabolism. We show herein that lactate fuels GB anaplerosis by replenishing the tricarboxylic acid (TCA) cycle in absence of glucose.

Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence.

Background: Substance use disorder emerges in a small proportion of drug users and has the characteristics of a chronic relapsing pathology.

Aims: Our study aimed to demonstrate and characterize the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm.

Methods: A cocaine-CPP paradigm in male Sprague-Dawley rats with an extinction period of 12 days and reinstatement was conducted.

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development.

Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12-15 months. In addition to highly proliferative and invasive properties, GB cells show cancer-associated metabolic characteristics such as increased aerobic glycolysis.