ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism.

Macroautophagy/autophagy is an essential catabolic process that targets a wide variety of cellular components including proteins, organelles, and pathogens. ATG7, a protein involved in the autophagy process, plays a crucial role in maintaining cellular homeostasis and can contribute to the development of diseases such as cancer. ATG7 initiates autophagy by facilitating the lipidation of the ATG8 proteins in the growing autophagosome membrane.

Orbital angular momentum beams generation from 61 channels coherent beam combining femtosecond digital laser.

We report on the use of a 61 beamlets coherent beam combination femtosecond fiber amplifiers as a digital laser source to generate high-power orbital angular momentum beams. Such an approach opens the path for higher-order non-symmetrical user-defined far field distributions.

Coherent beam combining of 61 femtosecond fiber amplifiers.

We report on the coherent beam combining of 61 femtosecond fiber chirped-pulse amplifiers in a tiled-aperture configuration along with an interferometric phase measurement technique. Relying on coherent beam recombination in the far field, this technique appears suitable for the combination of a large number of fiber amplifiers. The 61 output beams are stacked in a hexagonal arrangement and collimated through a high fill factor hexagonal micro-lens array.

Coherent beam combining of seven fiber chirped-pulse amplifiers using an interferometric phase measurement.

Coherent beam combining in tiled-aperture configuration is demonstrated on seven femtosecond fiber amplifiers using an interferometric phase measurement technique. The residual phase error between two fibers is as low as λ/55 RMS and a combination efficiency of 48% has been achieved. The combined pulses are compressed to 216 fs, delivering 71 W average power at a repetition rate of 55 MHz.

140 W peak power laser system tunable in the LWIR.

We present a high peak power rapidly tunable laser system in the long-wave infrared comprising an external-cavity quantum cascade laser (EC-QCL) broadly tunable from 8 to 10 µm and an optical parametric amplifier (OPA) based on quasi phase-matching in orientation-patterned gallium arsenide (OP-GaAs) of fixed grating period. The nonlinear crystal is pumped by a pulsed fiber laser system to achieve efficient amplification in the OPA. Quasi phase-matching remains satisfied when the EC-QCL wavelength is swept from 8 to 10 µm with a crystal of fixed grating period through tuning the pump laser source around 2 µm.