Publications by authors named "C Laprise"
Article Synopsis
- The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
- Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
- The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
In response to the current challenge in genetic studies to make new associations, we advocate for a shift toward leveraging population fine-scale structure. Our exploration brings to light distinct fine-structure within populations having undergone a founder effect such as the Ashkenazi Jews and the population of the Quebec' province. We leverage the fine-scale population structure to explore its impact on the frequency of rare variants.
View Article and Find Full Text PDFBackground And Methods: The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic siblings were recruited to date in the Zéro allergie cohort (ZAC) to better understand biological mechanisms underlying FA and OIT prognosis. The primary aims are to (a) better understand the genetic, epigenetic, transcriptomic, metabolomic, and microbial diversity associated with FA; (b) establish the multi-omics and microbial diversity profiles of children following OIT to identify predictive prognosis biomarkers, (c) make OIT more accessible to the population of the Saguenay-Lac-Saint-Jean region, and (d) build a biobank of data and biological material.
View Article and Find Full Text PDFArticle Synopsis
- Epidermolysis bullosa (EB) is a group of genetic skin disorders that lead to blistering and erosions on the skin due to minor trauma, with the simplex form (EBS) particularly linked to mutations in keratin genes K5 and K14.
- EBS results in painful skin lesions that significantly affect the quality of life, and research has identified key genes involved in inflammation and skin integrity through studies on mouse models and human cells.
- This review discusses the three subtypes of EBS, their genetic causes, gene expression patterns, molecular mechanisms, and recent advancements in treatment options.
Article Synopsis
- The study explores the link between genetic variants and the severity of COVID-19, particularly in patients with and without asthma.
- A genome-wide association study (GWAS) was performed on data from 2131 samples from the Biobanque québécoise de la COVID-19, revealing several genetic variants linked to severe COVID-19 symptoms.
- The findings indicate that understanding these genetic factors can improve knowledge about COVID-19 severity, illustrating differences in genetic profiles between asthmatic and non-asthmatic patients.