Publications by authors named "C Landmann"

Article Synopsis
  • The study examined the long-term effects of chronic diazepam use combined with alcohol on memory in aging mice, focusing on their potential impact on cognitive function.
  • Mice were divided into four groups and underwent 16 weeks of treatment with differing combinations of ethanol and diazepam, followed by memory tests and brain chemistry assessments.
  • Results indicated that while combined use during treatment negatively affected memory performance, there were no lasting effects on memory or hippocampal chemistry after discontinuation, suggesting benefits of stopping these substances.
View Article and Find Full Text PDF

In Brazil, the growth of agribusiness to the detriment of family agriculture occurred while concealing social, environmental and human health damages. The objective was to compare living and working conditions and access to health services between agricultural and non-agricultural workers. Data from the National Health Survey (PNS) on living and working conditions, sociodemographic, economic characteristics, and access to health services from a representative sample of the employed Brazilian population were adopted.

View Article and Find Full Text PDF

The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here, using live-cell imaging combined with micro-irradiation of single chromosomes, we analyze the dynamics of Polo and Mre11 at DNA lesions during mitosis in These two proteins display distinct kinetics.

View Article and Find Full Text PDF

Objective: Primary uterine leiomyosarcomas (ULMS) are rare, and the optimal treatment is controversial. We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS.

Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network (RCN).

View Article and Find Full Text PDF

Chromatid segregation must be coordinated with cytokinesis to preserve genomic stability. Here we report that cells clear trailing chromatids from the cleavage site by undergoing two phases of cell elongation. The first phase relies on the assembly of a wide contractile ring.

View Article and Find Full Text PDF