Publications by authors named "C Lamy"
Introduction: American College of Surgeons-Committee on Trauma (ACS-COT) defines minimum Standard Criteria (SC) for Level 1 trauma. In our hospital, discretion of prehospital personnel ("Paramedic Judgment" [PJ]) can initiate Full Trauma Triage Activation (FTTA) in the absence of ACS-COT criteria. The aim of this study was to evaluate overtriage and undertriage for PJ vs SC.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how amyloid deposits, detected through PET imaging, affect cognitive outcomes in stroke patients over a 5-year period.
- It included 91 patients with strokes and found that those with positive amyloid PET scans had significantly higher rates of developing dementia and cognitive impairment compared to those without.
- The findings indicate that amyloid positivity serves as a strong predictor for future cognitive decline, even after accounting for various factors like age and stroke type.
Purpose: The detection of circulating tumor DNA, which allows non-invasive tumor molecular profiling and disease follow-up, promises optimal and individualized management of patients with cancer. However, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge.
Experimental Design: We implemented a new highly sensitive strategy to detect base-pair resolution methylation patterns from plasma DNA and assessed the potential of hypomethylation of LINE-1 retrotransposons as a non-invasive multi-cancer detection biomarker.
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) shows significant genetic diversity within tumors, complicating targeted treatment approaches and making traditional imaging ineffective for detecting minimal residual disease (MRD).
- A study of 41 patients with resectable HNSCC found that circulating tumor DNA (ctDNA) can serve as a biomarker for assessing tumor heterogeneity and MRD, with notable detection rates at surgery and recurrence.
- The presence of ctDNA shortly after surgery correlated with disease recurrence, providing an early warning about potential relapse, thus supporting its role in post-operative monitoring and precision medicine strategies.
The forehead is the protective helmet of the brain, if we refer to the etymology of the word calvaria. Destroyed, it must be rebuilt; priority is given to its bone infrastructure, even though we can live without it, as long as the other tissues (skin, muscle, aponeurosis, meninge) are intact. Complex surgical project which will be mentioned when the multiplicity of techniques described demonstrates their imperfection and until now the best restoration of a missing tissue requires its replacement by the same tissue.
View Article and Find Full Text PDF