Rhinoconjunctivitis Symptoms in Children and Adolescents with Asthma: A Longitudinal Clustering Analysis.

Background: Rhinoconjunctivitis phenotypes are conventionally described based on symptom severity, duration and seasonality and aeroallergen sensitization. It is not known whether these phenotypes fully reflect the patterns of symptoms seen at a population level.

Objective: To identify phenotypes of rhinoconjunctivitis based on symptom intensity and seasonality using an unbiased approach and to compare their characteristics.

The effects of single testosterone administration and stress induction on steroid hormone levels in hair.

Hair steroid analysis is increasingly recognized for its ability to capture cumulative hormone secretion, thought to reflect an individual's response to long-term environmental conditions. Despite its growing use, the influence of single, isolated events on hair steroid concentrations remains underexplored. Our study therefore examined the effects of a single-dose transdermal testosterone administration (150 mg) and acute laboratory stress induction on hair testosterone and cortisol levels in a randomized, between-subject, placebo-controlled, and double-blind design.

Everyday helping is associated with enhanced mood but greater stress when it is more effortful.

Our affective states can influence whether we help others and after helping we often experience improved affect. One important factor determining whether we help, is the amount of effort involved. Using an ecological momentary assessment approach across two measurement bursts (N = 803; N = 303), we investigated the affective antecedents and consequences of everyday helping in terms of participants' self-reported momentary stress and mood valence, with a specific focus on the perceived amount of effort involved.