Publications by authors named "C Lamarque"
Background & Aims: To maximize utility and prevent premature liver transplantation (LT), a delayed LT strategy (DS) was adopted in France in 2015 in patients listed for any single HCC treated with resection or thermal ablation during the waiting phase. The DS involves postponing LT until recurrence. The purpose of this study was to evaluate the DS to make sure that it did not hamper pre- and post-LT outcomes.
View Article and Find Full Text PDFMetamaterials designate structures with properties exceeding bulk materials. Since the end of the 1990s, they have attracted ever-growing attention in many research fields such as electromagnetics, acoustics, and elastodynamics. This paper presents a numerical and experimental study on a locally resonant auxetic metamaterial for vibration isolation.
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- Research on targeting glucose metabolism in cancer has faced challenges due to ineffective anti-glycolytic agents and limited understanding of different cancer types' glucose use.
- A new compound, KL-11743, effectively inhibits class I glucose transporters, leading to decreased NADH levels and increased aspartate, indicating a shift to mitochondrial oxidative phosphorylation.
- The study found that mutations in key metabolic pathways make certain tumors, particularly SDHA-deficient cancers, more susceptible to GLUT inhibitors like KL-11743, showing potential for targeted cancer therapies.
Article Synopsis
- Aerobic glycolysis, discovered by Warburg as a key feature of cancer, is also involved in the activation and growth of immune cells.* -
- Glucose transporters (GLUTs) enable the transport of glucose across cell membranes and are potential targets for regulating aerobic glycolysis.* -
- The study focuses on developing and improving a new set of effective oral inhibitors that target GLUT1 and GLUT3, which could lead to new treatments for cancer and autoimmune diseases.*