The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies.

Background: High-fat diets (HFDs) have been associated with an increased risk of pancreatic cancer. In contrast, ketogenic diets (KDs) have been shown to display anti-tumor characteristics. The objective of this work was to evaluate the efficacy of a KD on late-stage pancreatic carcinogenesis in a genetically modified mouse model of pancreatic cancer [LSL-; -Cre (KC) mice], as well as its liver safety, and to compare it to that of an HFD.

Comparison of macrolitter and meso- and microplastic pollution on French riverbanks and coastal beaches using citizen science with schoolchildren.

Rivers are the major source of anthropogenic litter entering the ocean, especially plastic debris that accumulates in all ecosystems around the world and poses a risk to the biota. Reliable data on distribution, abundance, and types of stranded plastics are needed, especially on riverbanks that have received less attention than coastal beaches. Here, we present the citizen science initiative Plastique à la loupe (Plastic under the magnifier), which compares for the first time the distribution of different litter sizes (macrolitter and meso- and microplastics) over 81 riverbanks and 66 coastal beaches sampled in France between 2019 and 2021.

Monitoring misuse and abuse of psychoactive substances in France: Insights from substance abuse treatment facilities through the OPPIDUM program.

The OPPIDUM program was first created in 1990. It is an annual, repeated, cross-sectional, nationwide, multicenter program. Data are provided directly from users of psychoactive substances (PAS) seen in substance abuse treatment facilities.

A pilot case-control study on the fecal microbiota of pediatric functional abdominal pain-not otherwise specified and the role of early life stress.

Gut microbial features and the role of early life stress in pediatric functional abdominal pain-not otherwise specified (FAP-NOS) have never been investigated before. Here, we hypothesize that early life stress is more prevalent in FAP-NOS compared to healthy controls and that fecal microbial profiles and related metabolites differ between groups. In an international multicenter case-control study, FAP-NOS patients ( = 40) were compared to healthy controls ( = 55).