'Brown sugar' heroin intoxication and improvement of surrogate immunologic markers in HIV infection.

OBJECTIVE: To report on the unexpected improvement in major biological surrogate markers (CD4 T-cell count, HIV RNA viral load, and apoptosis level) during the periods of 'brown sugar' heroin intoxication (BSI) in 12 HIV-1-infected intravenous drug users, independently of their antiretroviral therapy, compared to the period of 'brown sugar' heroin withdrawal (BSW). METHODS: The patients were followed prospectively for a total of 417 months over 4 years. Twenty-four episodes of BSI and 24 periods of BSW were analyzed.

[Emergency consultations of foreign tourists in Paris in the month of August. 5 years of prospective surveillance (1992-1996)].

For five consecutive years, five major Parisian institutions in charge of emergencies have participated in a prospective collection of medical data for foreign patients visiting Paris in August; 4093 subjects have been studied. Gastroenteritis represented the main cause in calling on emergency medical care (14.5 to 21.

Malaria chemoprophylaxis of 3,446 French travelers departing from Paris to eight tropical countries.

Background: Each year more and more French travelers are visiting areas where malaria is endemic. The aim of this study was to assess prophylactic regimens used by French travelers and to determine whether they meet current published recommendations.

Methods: This 12 month transversal study (May 1, 1995 to April 31, 1996) was conducted in embarkment lounges of Roissy Charles de Gaulle Airport to eight "tropical" destinations.