Publications by authors named "C L van der Zee"
Background: Healthcare is responsible for 4% to 10% of carbon emissions worldwide, of which 22% is related to transport. Telemedicine emerged as a potential solution to reduce the footprint, for example, by reducing travel. However, a need to understand which variables to include in carbon footprint estimations in telemedicine limits our understanding of the beneficial impact telemedicine might have on our environment.
View Article and Find Full Text PDFArticle Synopsis
- The study explores a web-based tool for self-assessing visual acuity and refractive error in myopic children, with a focus on its effectiveness compared to traditional clinic measurements.
- The results demonstrated that children could accurately perform self-assessments at home, showing good agreement with clinical tests, although the web tool tended to underestimate visual acuity for poorer vision cases.
- The web-based refractive error assessments indicated greater myopia progression than those recorded in the clinic, suggesting this tool could be useful for ongoing monitoring in children.
The intraoperative optical coherence tomography (iOCT) is recently introduced in Descemet membrane endothelial keratoplasty (DMEK) surgery, which aims to increase clinical performance and surgery safety. However, the acquisition of this modality is a substantial investment. The objective of this paper is to report on the cost-effectiveness of an iOCT-protocol in DMEK surgery with the Advanced Visualization in Corneal Surgery Evaluation (ADVISE) trial.
View Article and Find Full Text PDFArticle Synopsis
- The Nucleocapsid protein (NCAP) of SARS-CoV-2 plays a vital role in the virus's function, with its self-assembly being central to this role.
- Analysis shows that NCAP has low-complexity domains (LCDs) similar to those in other proteins, which can form phase separation droplets and amyloid fibrils.
- The study reveals that the central LCD of NCAP can lead to both phase separation and amyloid formation, highlighting three adhesive segments that, when targeted by a new peptide (G12), can inhibit NCAP's self-assembly and exhibit antiviral effects against SARS-CoV-2.
Electron diffraction (MicroED/3DED) can render the three-dimensional atomic structures of molecules from previously unamenable samples. The approach has been particularly transformative for peptidic structures, where MicroED has revealed novel structures of naturally occurring peptides, synthetic protein fragments, and peptide-based natural products. Despite its transformative potential, MicroED is beholden to the crystallographic phase problem, which challenges its determination of structures.
View Article and Find Full Text PDF