Publications by authors named "C L de Mol"
Background: Primary lateral sclerosis (PLS) is a rare motor neuron disease characterized by upper motor neuron degeneration, diagnosed clinically due to the absence of a (neuropathological) gold standard. Post-mortem studies, particularly TDP-43 pathology analysis, are limited.
Methods: This study reports on 5 cases in which the diagnostic criteria for PLS were met, but in which neuropathology findings showed (partially) conflicting results.
Article Synopsis
- Neuroaxonal loss may begin early in multiple sclerosis (MS), but it's unclear if this is due to inflammation or neurodegeneration related to genetics and environment during childhood.
- A study analyzed the impact of genetic risk scores and childhood environmental factors, like Epstein-Barr virus exposure and parental smoking, on brain MRI outcomes in children aged 9 and 13.
- Findings suggest that genetic predisposition and exposure to parental smoking can reduce brain volumes, indicating potential strategies for early MS prevention in at-risk individuals.
Background: The impact of closed-loop control systems to titrate oxygen flow in critically ill patients, including their effectiveness, efficacy, workload and safety, remains unclear. This systematic review investigated the utilization of closed-loop oxygen systems for critically ill patients in comparison to manual oxygen titration systems focusing on these topics.
Methods And Findings: A search was conducted across several databases including MEDLINE, CENTRAL, EMBASE, LILACS, CINAHL, LOVE, ClinicalTrials.
Ringing a bell in healthcare: harnessing benefits, overcoming implementation challenges, and bridging knowledge gaps of Closed-Loop Oxygen Control systems (CLOCs).
Einstein (Sao Paulo)
March 2024
Aims: To meet the flexible learning needs of pathology residents preparing for national board examinations, a joint distance learning approach was developed using both asynchronous and synchronous activities with whole slide images, drawing on empirical educational research on online distance learning.
Methods: In a case study of an implementation of the designed joint distance learning approach with a geographically dispersed group of pathology residents in Finland, the participants' perceptions were measured with a 12-item questionnaire covering the value of the learning opportunity, the quality of the sociocognitive processes and their emotional engagement and social cohesion. Communication during the online session was also recorded and analysed to provide objectivity to the self-report data.