Inhalation and intravenous studies of UF6/UO2F2 in dogs.

Nineteen UF6/UO2F2 inhalation studies were undertaken in purebred, female beagle dogs (N = 16) to examine inter alia, (a) the possible relations of exposure, whole body, lung and renal uranium levels to excretion rates; (b) the threshold U6+ dose and renal concentration for renal injury; (c) the distribution and retention functions for U6+ in major tissues; (d) biochemical indicators of renal injury; and (e) aspects of U-induced tolerance. Each of these issues was investigated in the context of the chemical toxicity of U6+ following brief exposures to 235UO2F2 in the presence or absence of HF (the decomposition products of 235UF6). Both gamma-(235U) and alpha-(234U) counting methods were applied.

The disposition of coal dusts in the lungs and tracheobronchial lymph nodes of dogs.

The pulmonary disposition, histopathology and lymphatic uptake of anthracite (Tamaqua) and bituminous (Lower Kittaning) coal dusts were measured as part of a pulmonary retention study which revealed a mean half-time of 1.92 years in dogs (Morrow et al. 1981).

Effects in the liver of methylene chloride inhaled alone and with ethyl alcohol.

When high concentrations of methylene chloride in combination with high concentrations of ethanol were inhaled for one day by guinea pigs, the extent of the hepatic damage induced suggested an antagonism between the effects of the two agents. However, exposure for five days to approximately 500 ppm of methylene chloride plus high concentrations of ethanol suggested ethanol may potentiate the effects of methylene chloride.