RIPK3: The Deadpool of neuronal cell death proteins?

Receptor interaction kinase 3 (RIPK3) is a key mediator of necroptosis, initiating programmed cell death with mercenary efficiency in multiple neurodegenerative diseases. However, in this issue of Immunity, Estevez et al. demonstrate that RIPK3, like the character Deadpool, exists in duality and can also be a force for good by preventing excitotoxic neuronal death during orthoflavivirus encephalitis.

Associations among threat prediction error, prediction change, and anxiety during an exposure therapy analogue in adults with healthy to clinical social anxiety.

Contemporary exposure therapy models for anxiety argue that exposures must generate threat prediction error to be effective. More research is needed to test this claim in clinical settings. This study explored how threat prediction error learning relates to outcomes during an exposure analogue procedure.

Exploring the digital extremist ecosystem: a preliminary analysis of hateful posts on Mod DB.

The last 4 years have seen a stark increase in research on extremist activities in digital gaming spaces, particularly on gaming- and gaming-adjacent platforms. However, one area that has not received much attention so far are mod forums. While a large number of mods with hateful content have been created over the last two decades, the forums used to disseminate and discuss such mods have not yet been examined by extremism researchers.

Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain.

A midline in the developing central nervous system allows symmetric distribution of neural progenitors that later establish functional, bilaterally symmetric neural circuits. In the zebrafish hindbrain, a midline forms early during neurulation as a result of coordinated cell convergence and midline-crossing cell divisions (C-divisions). These processes are controlled by the Wnt/planar cell polarity (PCP) pathway that positions progenitors close to a presumptive midline to perform C-divisions.

Preeclampsia in mice carrying fetuses with APOL1 risk variants.

African-American women have a maternal mortality rate approximately three times higher than European-American women. This is partially due to hypertensive disorders of pregnancy, including preeclampsia. Fetal high-risk genotype increases preeclampsia risk, although mechanisms remain elusive.