Publications by authors named "C L Valente"
Objective: The frequency of obstructive sleep apnea (OSA) in patients with idiopathic pulmonary fibrosis (IPF) is high. The clinical course of non-IPF interstitial lung disease (ILD) can be similar to that of IPF. We sought to assess the frequency and predictors of OSA in patients with non-IPF fibrotic ILD, as well as the impact of positive airway pressure (PAP) therapy on the quality of life of such patients.
View Article and Find Full Text PDFIntroduction/objectives: Studies comparing the effects of antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation (AF) are currently limited; therefore, this study aimed to report detailed data on the efficacy and therapy-related side-effects (TRSEs) of different antiarrhythmic protocols in dogs with secondary AF.
Animals, Materials, And Methods: Dogs with secondary AF treated with combination therapy with diltiazem and digoxin (CT), diltiazem monotherapy (MT), digoxin monotherapy (MT), or amiodarone monotherapy (MT) were retrospectively evaluated. Signalment, clinical, diagnostic, therapeutic, and outcome data were retrieved.
Article Synopsis
- A 79-year-old man presented with fatigue and melena, leading to a diagnosis of severe iron-deficiency anemia.
- Capsule endoscopy identified submucosal vascular lesions in the jejunum and bleeding in the ileum, suggestive of Blue Rubber Bleb Nevus Syndrome (BRBNS).
- An exploratory laparoscopy resulted in the resection of a 120 cm segment of the intestine, which confirmed the diagnosis through histological examination.
Despite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications. Gene therapy in experimental models has emerged as effective treatment targeting specific neuronal populations in the epileptogenic focus. When combined with an external chemical activator using chemogenetics, it also becomes an "on-demand" treatment.
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- Adenosine acts as a natural anticonvulsant through adenosine receptors (AR), but developing drugs that target these receptors has been challenging due to potential cardiac side effects.
- The study examined the effects of a selective AR agonist called MRS5474 on excitatory and inhibitory signals in the hippocampus, using both rodent and human tissue samples.
- Results showed that MRS5474 does not affect normal excitatory signals but enhances GABAergic currents in tissue from patients with epilepsy, suggesting its potential as a targeted antiseizure medication through activation of AR in epileptic conditions.