Publications by authors named "C L Underwood"
Background/objective: , the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one of the most infectious causes of foetal death in sheep worldwide. Although the disease can be controlled using commercial inactivated and live whole-organism vaccines, there are issues with both, particularly concerning efficacy and safety. Recently, we have described the development of a new COMC (chlamydial outer membrane complex) vaccine based on a detergent-extracted outer membrane protein preparation of the pathogen, which can be delivered in a single inoculation and is both efficacious and safe.
View Article and Find Full Text PDFGut inflammation is a salient prodromal feature of Parkinson's disease (PD) implicated in pathologic processes leading to nigrostriatal dopaminergic degeneration. However, existing rodent models of PD are suboptimal for investigating the interaction between gut inflammation and neuropathology. This study aimed to develop a rat model of PD in which gut inflammation exacerbated PD symptoms induced by a parkinsonian lesion.
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- Vaccinations are vital for pediatric care, especially for children with cancer, as they help prevent infections and improve survival rates, yet the situation in Latin America and the Caribbean is under-researched.
- A survey of healthcare providers caring for children with cancer across 20 countries revealed that a significant majority recommend vaccinations, but many struggle with consistent guideline adherence.
- While providers generally support vaccinating these children, particularly against influenza, variability in their recommendations points to the need for improved strategies and support at institutional and governmental levels to enhance vaccination coverage.
Bilateral diaphragmatic paralysis in a weanling donkey jack.
J Vet Emerg Crit Care (San Antonio)
December 2024
Objective: To describe the clinical presentation and diagnosis of bilateral diaphragmatic paralysis in a weanling miniature donkey jack.
Case Summary: A 5-month-old miniature donkey jack presented to a tertiary care facility for fever, cough, and increased respiratory rate and effort initially unresponsive to treatment with antimicrobials and anti-inflammatories. Clinical and diagnostic evaluations found no evidence of upper respiratory obstruction or bacterial pneumonia.
Article Synopsis
- Ovine enzootic abortion is a highly infectious disease causing fetal death in small ruminants, but it can be managed with vaccines, which need better safety for both sheep and humans.
- A new prototype vaccine has been created that outperforms existing commercial vaccines in safety and efficacy when given in two doses three weeks apart.
- The recent study shows that this vaccine remains effective even with a single dose or a reduced antigen amount, indicating potential for commercial use if the ideal dosage is determined.