Publications by authors named "C L Scaglione"
Article Synopsis
- The study investigates the differences in clinical features and spread risk of oromandibular dystonia (OMD) between idiopathic and acquired subtypes, based on a retrospective analysis of 273 patients from the Italian Dystonia Registry.
- It was found that idiopathic cases mainly exhibited sensory tricks and a family history, with a notable 34% of focal OMD patients experiencing spread within the first five years.
- The research highlights a potential link between sensory tricks and OMD spread, suggesting estrogen's role in dystonia development and providing a basis for further studies on underlying mechanisms and treatment options.
Background: Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and a male preponderance in limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether sex-related differences exist in expressing other dystonia-associated features and dystonia spread.
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- A study was conducted to explore the connection between thyroid diseases and idiopathic adult-onset dystonia (IAOD) by examining 1,518 patients from the Italian Dystonia Registry.
- Out of these patients, 11% were diagnosed with hypothyroidism and 2.8% with hyperthyroidism, with the groups showing comparable demographics but a higher prevalence of women in thyroid-affected groups.
- The research found no significant link between thyroid conditions and specific characteristics of dystonia, including its distribution and associated features, suggesting that thyroid diseases do not impact the course of IAOD.
Background: Although acquired dystonia may develop following ischaemic/haemorrhagic stroke, the relationship between cerebrovascular disease and idiopathic dystonia has been poorly investigated. This cross sectional study aimed at evaluating the impact of cerebrovascular risk factors on the clinical expression of idiopathic adult onset dystonia (IAOD), with reference to dystonia localization and dystonia-associated features.
Methods: Data were obtained from the Italian Dystonia Registry.
Background: To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias.
Objectives: To compare demographic data and clinical features in patients with adult-onset acquired and idiopathic dystonias.
Methods: Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult-onset dystonia.