Publications by authors named "C L Sawyers"
Article Synopsis
- Lineage plasticity in cancer affects treatment effectiveness, and this study presents a new in vivo method to explore neuroendocrine lineage changes in prostate cancer progression.* -
- Researchers found that mouse prostate organoids with specific mutations form aggressive neuroendocrine prostate cancer (NEPC) when Rb1 is deleted, but only in the right in vivo environment, unlike traditional organoid cultures.* -
- The study shows that ASCL1 cells originate from KRT8 luminal cells and that losing Ascl1 in NEPC leads to temporary regression but later recurrence; however, deleting it before transplantation prevents lineage changes and results in more treatable adenocarcinomas.*
Article Synopsis
- Targeting cell surface molecules with therapies like radioligands and antibodies has been effective in treating various cancers, but the impact of lineage plasticity on these markers is still poorly understood.
- A specific example of lineage plasticity is the transformation of prostate adenocarcinoma to neuroendocrine prostate cancer, which poses significant treatment challenges and worsens patient survival rates.
- Research using advanced single-cell analyses and large tumor sample studies revealed significant phenotypic variability and shared gene-regulatory networks between NEPC and small cell lung cancer, raising concerns about the effectiveness of current therapies while suggesting potential for better patient selection in clinical trials.
Adolescent risk-taking has been attributed to earlier-developing motivational neurocircuitry that is poorly controlled by immature executive-control neurocircuitry. Functional magnetic resonance imaging findings of increased ventral striatum (VS) recruitment by reward prospects in adolescents compared to adults support this theory. Other studies found blunted VS recruitment by reward-predictive cues in adolescents compared to adults.
View Article and Find Full Text PDFTherapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the expression patterns of the target proteins in tumor tissues is required. In castration-resistant prostate cancer (CRPC), agents targeting prostate-specific membrane antigen (PSMA) have demonstrated clinical activity.
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