Is Internet Gaming Disorder Associated with Trauma and Stress? Testing the Trauma Model of Addiction Among Young Adults.

Internet gaming disorder (IGD) is a growing public health concern, with longitudinal studies linking it to a range of negative outcomes, including psychological distress and poor academic achievements. While the trauma model has been applied to other addictive behaviors, little is known about the relationship between childhood trauma, trauma-related symptoms, and IGD symptoms. This preliminary study investigated whether childhood betrayal trauma would have a stronger relationship with IGD symptoms than non-betrayal trauma and whether IGD symptoms would be associated with interpersonal stress and trauma-related symptoms.

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.

Heart failure (HF) is a prominent fatal cardiovascular disorder afflicting 3.4% of the adult population despite the advancement of treatment options. Therefore, a better understanding of the pathogenesis of HF is essential for exploring novel therapeutic strategies.

TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer.

Cisplatin causes permanent hearing loss or cisplatin-induced ototoxicity in over 50% of treated patients with cancer, leading to significant social and functional limitations. Interindividual variability in developing hearing loss suggests the role of genetic predispositions to cisplatin-induced hearing loss. We investigated genetic associations between cisplatin-induced ototoxicity and toll-like receptor 4 (TLR4), an immune receptor known to mediate inflammatory responses to cisplatin.

Impact of teleretinal screening program on diabetic retinopathy screening compliance rates in community health centers: a quasi-experimental study.

Background: Diabetic retinopathy (DR) remains a leading cause of preventable blindness, with inadequate screening rates even in urban areas with high concentrations of medical professionals. While medical guidelines recommend annual diabetic retinopathy screening for patients with diabetes mellitus, adherence to these recommendations remains low. This study evaluates the impact of a novel teleretinal DR screening program on screening compliance across urban community health centers in Boston, Massachusetts.

A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Rationale: Critically ill adults are at risk for a variety of distressing and consequential symptoms both during and after an ICU stay. Management of these symptoms can directly influence outcomes.

Objectives: The objective was to update and expand the Society of Critical Care Medicine's 2018 Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.