Some industrial developments and applications of multidimensional techniques.

Industrial analytical chemistry includes the measurement of the elemental composition and structure of molecules; the measurement of the concentration of specific molecules, atoms, and ions in contact with other molecules, atoms, and ions, the measurement of the energy and speed with which these reactions occur; and the separation of molecules, atoms, and ions specifically from other molecules, atoms and ions. It is also the measurement of the physical (interaction) and chemical (reaction) behavior of collections of molecules and how this behavior is controlled by the presence of other molecules and ions. Many excellent devices for separation and measurement have been developed to accomplish these tasks.

Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes.

The stereochemistry of the metabolism of vic-dihaloalkanes to alkenes has been studied. This glutathione-dependent biotransformation may occur by two mechanism. The first mechanism involves the nucleophilic attack of glutathione on the substrate resulting in S-(beta-haloalkyl)glutathione formation; subsequent attack of a second thiol on the sulfur atom of the conjugate yields glutathione disulfide, ethylene, and halide ion.

Identification of the major urinary metabolites of acrylonitrile in the rat.

The metabolism of acrylonitrile (AN) in rats was studied in conjunction with toxicological and pharmacokinetic studies to help assess the potential hazard of exposure to AN in the workplace. Rats were administered 30 mg/kg [1-14C] AN or [2,3-14C] AN orally. Radiolabeled metabolites excreted in the urine during the first 16 h were separated by ion-exclusion liquid chromatography and identified (after derivatization) by gas chromatography-infrared spectroscopy and/or gas chromatography-mass spectrometry.