Publications by authors named "C L Patti"
Colonization by multidrug-resistant (MDR) bacteria and related bloodstream infections (BSI) are associated with a high rate of mortality in patients with hematological malignancies after intensive chemotherapy and allogeneic stem cell transplantation (allo-SCT). In this retrospective study, we analyzed the outcomes of patients colonized with MDR bacteria (primarily carbapenem-resistant , KPC), before allo-SCT. We also investigated the feasibility and safety of an antimicrobial de-escalating approach in these patients.
View Article and Find Full Text PDFAlthough recent evidence suggests that myeloid clonal hematopoiesis (M-CH) may influence lymphoma clinical outcome, its impact in mantle cell lymphoma (MCL) remains unclear. Here, we report a comprehensive NGS-based analysis of the M-CH mutational landscape at baseline and follow-up in patients enrolled in the Fondazione Italiana Linfomi (FIL) MCL0208 phase 3 trial (NCT02354313), evaluating lenalidomide maintenance versus observation after chemoimmunotherapy and autologous stem cell transplantation (ASCT) in untreated young MCL patients. Overall, 254/300 (85%) enrolled patients (median age 57 years [32-66]) had a baseline sample available for CH analysis.
View Article and Find Full Text PDFArticle Synopsis
- Acute myeloid leukemia (AML) relapse is a major cause of mortality following allogeneic stem cell transplants, but using Sorafenib for maintenance post-transplant has shown to lower relapse and death rates in FLT3+ AML patients.
- In a study with 29 adult FLT3m AML patients who received allo-SCT, Sorafenib was administered as maintenance therapy after their initial treatment with midostaurin and chemotherapy.
- Results indicated that 62% of patients received Sorafenib; those who did had significantly improved 2-year overall survival (94%) and lower relapse rates (11%) compared to the whole population (76% OS, 28% CIR).