Publications by authors named "C L Parish"
Immune checkpoint therapy targeting the PD-1/PD-L1 axis has revolutionised the treatment of solid tumors. However, T cell exhaustion underpins resistance to current anti-PD-1 therapies, resulting in lower response rates in cancer patients. CD28 is a T cell costimulatory receptor that can influence the PD-1 signalling pathway (and vice versa).
View Article and Find Full Text PDFHeteroaromatic species are commonly found in complex gaseous mixtures, from tobacco smoke to petroleum and asphaltene combustion products. At high temperatures, C-H bond rupture produces various dehydro radical isomers. We have used the spin-flip formulation of equation-of-motion coupled cluster theory with single and double substitutions (EOM-SF-CCSD) to characterize the energies and wave functions of the lowest lying singlet and triplet states of the diradical (2,3), (2,4), (2,5), and (3,4) di-dehydro isomers of pyrrole, furan, and thiophene.
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- The study investigates the thermal decomposition of 2-cyclopentenone during biomass pyrolysis, utilizing both experimental techniques and theoretical models.
- Gas-phase pyrolysis experiments were conducted at high temperatures, revealing various products like carbon monoxide and different hydrocarbons through FTIR spectroscopy.
- Five distinct decomposition pathways were identified, including multiple H atom migrations and C-C bond ruptures, leading to the formation of compounds such as acrolein, propane derivatives, and intermediates like cyclopropenone.
Article Synopsis
- Liquid chromatography-mass spectrometry (LC-MS) is highlighted as a crucial technique for quickly measuring oligonucleotides, essential for understanding their biological functions and developing diagnostic tools.
- The study introduces a high-throughput LC-MS/MS method validated with a MALAT-1 Antisense oligonucleotide, showcasing effective biological sample purification and analysis techniques.
- Key focus areas include optimizing the measurement sensitivity, using a risk-free internal standard, automating sample preparation to enhance consistency, and comparing purification methods, ultimately leading to effective quantification in biological samples like cerebrospinal fluid and plasma.
Metallatranes and their analogous fused ring [3.3.0] bicyclic compounds, quasimetallatranes, have emerged as fascinating molecular systems with intriguing structural, bonding, and conformational properties.
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