The burden of dengue in South American countries, 1990-2019: Estimates from the Global Burden of Disease study 2019.

Objectives: To describe the main dengue metrics generated by the Global Burden of Disease (GBD) Study 2019 for South American countries between 1990 and 2019.

Study Design: A descriptive study was carried out using the metrics obtained by the GBD Study 2019.

Methods: The metrics of incidence, years of life lost due to premature death (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) were evaluated, grouped by sex and country, between 1990 and 2019.

Cost Analysis of Epilepsy Healthcare in Adults: A Direct Cost Estimate From a Colombian Perspective.

Objectives: To estimate the direct healthcare costs related to outpatient care and hospital stays for adults with epilepsy in the context of the Colombian healthcare system.

Methods: A cost analysis was conducted from a base case, which included direct medical costs related to diagnosis, follow-up, pharmacological and surgical treatment, and in-hospital care for status epilepticus. A Delphi panel was carried out to identify and quantify cost-generating events.

Role of Polyphosphate as an Inorganic Chaperone to Prevent Protein Aggregation Under Copper Stress in .

Polyphosphates are biopolymers composed of phosphate monomers linked by high-energy phosphoanhydride bonds. They are present across all life domains, serving as a source of energy, metal chelators, and playing a crucial role in stress defense. In , polyphosphates also function as inorganic molecular chaperones.

The Challenge of Deep Learning for the Prevention and Automatic Diagnosis of Breast Cancer: A Systematic Review.

Objectives: This review aims to evaluate several convolutional neural network (CNN) models applied to breast cancer detection, to identify and categorize CNN variants in recent studies, and to analyze their specific strengths, limitations, and challenges.

Methods: Using PRISMA methodology, this review examines studies that focus on deep learning techniques, specifically CNN, for breast cancer detection. Inclusion criteria encompassed studies from the past five years, with duplicates and those unrelated to breast cancer excluded.

Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells.

Introduction: During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA and NR are considered safe dietary supplements, it is equally important to understand their function in normal cells and in disease states.