Fracture healing assessment comparing stiffness measurements using radiographs.

Based on published reports, we presumed radiographs would be unreliable as a sole measure of fracture healing. To confirm this presumption we correlated radiographic fracture healing assessments with fracture stiffness measurements. We showed 100 plain radiographs of fractures with corresponding fracture stiffness measurements to 92 observers.

mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.

1. Interpretation of novel drug exposure and toxicology data from the dog is tempered by our limited molecular and functional knowledge of dog cytochromes P450 (CYPs). The aim was to study the mRNA and protein expression of hepatic dog CYPs in relation to the metabolism of substrates of human CYP, particularly those of the CYP2C subfamily.