Publications by authors named "C L M Krieckaert"
Article Synopsis
- The 'MHC-I-opathy' concept refers to a group of inflammatory diseases linked to the major histocompatibility complex class I, with recognized conditions including spondyloarthritis and psoriasis, all associated with specific genetic variants.
- There is a significant challenge in understanding and treating these disorders due to differences in patient symptoms and insufficient research on the MHC-I pathway.
- The text advocates for a collaborative approach involving diverse medical and research disciplines to standardize disease definitions, explore genetic factors, and improve therapeutic strategies, ultimately aiming to enhance patient care.
The objectives of this review were to collect and summarise evidence on therapeutic drug monitoring (TDM) of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases and to inform the EULAR Task Force for the formulation of evidence-based points to consider. A systematic literature review (SLR) was performed, covering technical aspects and (clinical) utility of TDM, to answer 13 research questions. MEDLINE, Embase and Cochrane were searched until July 2020.
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- The objective of the study was to create guidelines for therapeutic drug monitoring (TDM) of biopharmaceuticals used in inflammatory rheumatic and musculoskeletal diseases (RMDs), developed by a multidisciplinary task force from eight European countries.
- The task force established six key principles and 13 specific points regarding TDM based on systematic literature reviews and expert agreement, with high levels of consensus (8.4 to 9.9 on a 10-point scale) on these recommendations.
- The guidelines emphasize that while proactive TDM is generally not recommended, reactive TDM may be useful in certain cases; however, there is a need for more high-quality research to support its effectiveness and safety in
Background: Research on the disease severity of COVID-19 in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) has been inconclusive, and long-term prospective data on the development of SARS-CoV-2 antibodies in these patients are lacking.
Methods: Adult patients with rheumatic IMIDs from the Amsterdam Rheumatology and Immunology Center, Amsterdam were invited to participate. All patients were asked to recruit their own sex-matched and age-matched control subject.