"The Gordian knot of it he will unloose": Lessons learned from studies of half-hitch surgical knots and implications for practicing surgeons: A systematic review.

Background: Insecure surgical knots can cause surgical complications ranging from wound dehiscence to massive exsanguination and death. Most surgeons tie half-hitch knots, of which some configurations are prone to slippage. We aim to characterize the securities of different half-hitch knot configurations.

The deubiquitinase Usp7 in is required for synaptonemal complex maintenance.

Meiosis is a form of cell division that is essential to sexually reproducing organisms and is therefore highly regulated. Each event of meiosis must occur at the correct developmental stage to ensure that chromosomes are segregated properly during both meiotic divisions. One unique meiosis-specific structure that is tightly regulated in terms of timing of assembly and disassembly is the synaptonemal complex (SC).

Using publicly available, interactive epidemiological dashboards: an innovative approach to sharing data from the Rakai Community Cohort Study.

Objectives: Public sharing of de-identified biomedical data promotes collaboration between researchers and accelerates the development of disease prevention and treatment strategies. However, open-access data sharing presents challenges to researchers who need to protect the privacy of study participants, ensure that data are used appropriately, and acknowledge the inputs of all involved researchers. This article presents an approach to data sharing which addresses the above challenges by using a publicly available dashboard with de-identified, aggregated participant data from a large HIV surveillance cohort.

Interleukin (IL)-1/IL-6-Inhibitor-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses.

Background: After introducing IL-1/IL-6 inhibitors, some patients with Still and Still-like disease developed unusual, often fatal, pulmonary disease. This complication was associated with scoring as DReSS (drug reaction with eosinophilia and systemic symptoms) implicating these inhibitors, although DReSS can be difficult to recognize in the setting of systemic inflammatory disease.

Objective: To facilitate recognition of IL-1/IL-6 inhibitor-DReSS in systemic inflammatory illnesses (Still/Still-like) by looking at timing and reaction-associated features.

Impacts of groundwater dynamics around a macro-tidal river on agricultural soil salinity.

Estuaries are vulnerable to oceanic and atmospheric climate change. Much of the research investigating climate change impacts on estuaries is focused on saltwater intrusion within surface water due to drought and rising sea levels, with implications for ecosystems and humans. Groundwater and soil near estuaries may also be influenced, as estuary salinity and hydraulic head changes can impact soils and aquifers not previously at risk of salinization.