Publications by authors named "C L Kane"
Background: Adverse pathology (AP) is often used as an intermediate end point for long-term outcomes in men with prostate cancer (PCa) who are active surveillance candidates. The association between a commonly used AP definition and long-term outcomes was tested, which identified definitions more strongly linked to a high risk of metastasis.
Methods: Data were reviewed from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing radical prostatectomy (RP) from 1988 to 2020 at nine Veterans Affairs hospitals.
Laws for health and care worker protection and rights: A study of 182 countries.
PLOS Glob Public Health
December 2024
The unprecedented and multi-faceted challenges health and care workers faced during the COVID-19 pandemic inspired the world's health ministers to call for a new Global Health and Care Worker Compact at the 74th World Health Assembly in 2021. The Care Compact identifies key areas where governments can use law and policy to prevent harm, provide support, ensure inclusivity, and safeguard rights of health and care workers toward improving population health. Using policy surveillance methods, we conducted an empirical analysis of the national law and policy environments on health and care workers' protection and rights in 182 countries.
View Article and Find Full Text PDFPurpose: The availability of targeted therapies for advanced prostate cancer led to the expansion of national guidelines recommending germline genetic testing. The aim of this study was to describe recent trends in germline test ordering patterns for patients with prostate cancer.
Materials And Methods: A retrospective cohort analysis of patients with prostate cancer who underwent germline testing through a single commercial laboratory (Invitae Corporation) between 2015-2020 was performed.
Article Synopsis
- The study analyzes the first major beaching of holopelagic Sargassum in Senegal, emphasizing its environmental impact and economic potential.
- It identifies the dominant morphotype (S. fluitans III) and finds unique biochemical properties, such as lower arsenic but higher cadmium and mercury levels compared to other regions.
- The research suggests using the Sargassum for applications in animal feed and agriculture, while advocating for African inter-governmental collaboration to address the increasing frequency of Sargassum beaching events.
Article Synopsis
- Cytokine release syndrome, often linked to T-cell therapies like talquetamab, causes an increase in interleukin-6 (IL-6), which might inhibit certain liver enzymes (cytochrome P450).
- The study aimed to assess how elevated IL-6 affects the metabolism of other drugs by looking at both standard and extreme IL-6 levels after talquetamab treatment.
- Results showed that while normal IL-6 levels had no significant impact on drug interactions, elevated IL-6 could moderately affect specific liver enzymes, with potential effects peaking 7 to 9 days after the start of treatment.