Impact of viral eradication by direct-acting antivirals on clinical outcomes after curative treatment for hepatitis C virus-associated hepatocellular carcinoma.

Background: It is not clear that antiviral therapy for hepatitis C virus (HCV) after recovery from curative treatment for hepatocellular carcinoma (HCC) has an effect on suppressing recurrence or improving survival rates.

Objectives: We analyzed the impact of eradication by interferon (IFN)-free direct-acting antiviral (DAA) therapy on clinical outcomes of patients with HCV-associated HCC who underwent curative treatment.

Design: This was a retrospective study.

Heterologous prime-boost immunization of two-component vaccine candidate PWDVax protected pigs against F18 enterotoxigenic post-weaning diarrhea.

Post-weaning diarrhea (PWD) is associated predominantly with enterotoxigenic (ETEC) and continuously causes significant economic losses to swine producers worldwide. Currently, there are no effective countermeasures against this significant swine disease. Challenges persist in developing vaccines against PWD since ETEC strains produce heterogeneous virulence factors, including F4 (K88) and F18 fimbria and heat-labile toxin (LT), heat-stable toxin type I (STa), heat-stable toxin II (STb), and Shiga toxin type 2e (Stx2e, also causes edema disease).

Financial Performance of Hospital Telehealth Adopters, Nonadopters, and Switchers: A Rural-Urban Comparison.

Goals: The adoption of telehealth in healthcare delivery has transformed patient treatment options. Urban and rural hospitals are increasingly using telehealth to reach more patients, improve patient engagement, and increase healthcare quality. Hospitals experience the operational benefits of adopting telehealth through improving clinical workflow, increasing efficiency, and improving patient satisfaction.

Building and Developing a Tool (PANDEM-2 Dashboard) to Strengthen Pandemic Management: Participatory Design Study.

Background: The COVID-19 pandemic exposed challenges in pandemic management, particularly in real-time data sharing and effective decision-making. Data protection concerns and the lack of data interoperability and standardization hindered the collection, analysis, and interpretation of critical information. Effective data visualization and customization are essential to facilitate decision-making.

A cumulative strain model for chronic pain and multimorbidity.

Background: Chronic pain often occurs amidst multimorbidity. The proposed cumulative strain model postulates diverse but interlinked biological mechanisms of strain playing a role in the causation of multiple chronic conditions, including chronic pain. Modulators of strain include mindbody, connection, activity, nutrition and biomedical aspects.