Publications by authors named "C L Hamill"
Inequities Associated With Advanced Stage at Presentation of Head and Neck Cancer: A Systematic Review.
JAMA Otolaryngol Head Neck Surg
August 2024
Importance: Social determinants of health (SDoH) are defined by a wide range of factors (eg, built environment, economic stability, education level, discrimination, racism, access to health care). Advanced stage at presentation or delayed diagnosis heavily influences health outcomes in patients with head and neck cancer (HNC). While the drivers of advanced-stage presentation come from a multitude of sources, SDoH plays an outsized role.
View Article and Find Full Text PDFIntroduction: Pedicle subtraction osteotomy (PSO) is a complex surgical procedure that provides correction of moderate sagittal imbalance. Surgical complications have adverse effects on patient outcomes and healthcare costs, making it imperative for clinical researchers to focus on minimizing complications. However, when it comes to risk modeling of PSO surgery, there is currently no consensus on which patient characteristics or measures should be used.
View Article and Find Full Text PDFArticle Synopsis
- Many enzymes show unique behavior not justified by classic Arrhenius equations, leading to curved plots under certain conditions.
- The study explores how negative activation heat capacity (Δ) in the enzyme MalL affects these curves and uses both experimental data and molecular dynamics simulations to evaluate its conformational changes.
- A two-state model extending existing theories effectively explains the observed behavior, helping to reconcile findings from MalL with previous research on enzyme kinetics.
Introduction: Head and neck malignancy treatment often involves invasive surgeries, necessitating effective postoperative pain control. However, chronic reliance on opioid medications remains a challenge for many patients after surgery. Multimodal analgesia (MMA) within enhanced recovery after surgery protocols has shown success in limiting narcotic pain medications for other cancer types.
View Article and Find Full Text PDFObjective: To determine differences in post-treatment QoL across treatment settings in patients receiving adjuvant radiation therapy for head and neck squamous cell carcinoma (HNSCC).
Methods: This was a prospective observational cohort study of patients with HNSCC initially evaluated in a head and neck surgical oncologic and reconstructive clinic at an academic medical center (AMC). Participants were enrolled prior to treatment in a prospective registry collecting demographic, social, and clinical data.