Publications by authors named "C L Halsey"
T-cell receptor recognition of cognate peptide-MHC leads to the formation of signalling domains and the immunological synapse. Because of the close membrane apposition, there is rapid exclusion of CD45, and therefore LCK activation. Much less is known about whether spatial regulation of the intracellular face dictates LCK activity and TCR signal transduction.
View Article and Find Full Text PDFSevere steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study.
Br J Haematol
October 2024
Article Synopsis
- Steroids play a key role in treating acute lymphoblastic leukaemia (ALL) in young patients, but can lead to serious neuropsychiatric symptoms (SRNS).
- A study examined 1813 patients from 2000 to 2017, finding that 5.2% experienced significant SRNS, mainly during the early and intensification phases of treatment, with dexamethasone linked to 86% of cases.
- The most common SRNS symptoms were psychosis, agitation, and aggression, and 87% of those affected received pharmacological treatment, highlighting the need for more awareness and research on managing SRNS in ALL therapy.
Objective: The Buried in Treasures (BIT) workshop is a promising treatment for hoarding disorder (HD), though many participants struggle with home uncluttering. This randomized waitlist-controlled trial investigated the efficacy of a version of BIT, augmented with in-home uncluttering practice (BIT+).
Method: Adults (N = 41) with hoarding disorder were recruited from the community and randomly assigned to BIT+ or waitlist.
In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted γδ-T cells undergo further functional maturation after exiting the thymus.
View Article and Find Full Text PDFBackground: This study was initiated and co-designed by a Participant and Public Involvement (PPI) group attached to HOMESIDE, a randomized controlled trial that investigated music and reading interventions for people living with dementia and their family caregivers across five countries: Australia, Germany, Norway, Poland, and the UK. The aim was to capture experiences of PPI across the five countries, explore the benefits and challenges of PPI in dementia research, and identify contributions made to the study.
Methods: We surveyed PPI members and academic researchers who collaborated on the HOMESIDE study.