[Beta 2-microglobulin and tumors of the central nervous system].

In 60 patients with tumours of the central nervous system (50 intracranial, 10 intraspinal) the beta 2-microglobulin in serum and cerebrospinal fluid was examined. The frequency of pathological finding was in both examined fluids considerable and differed with regard to the type and site of the tumours; it was particularly high in intracranial gliomas (in serum 87.1%, in cerebrospinal fluid 74.

[The significance of isoelectric focusing of unconcentrated cerebrospinal fluid in the detection of oligoclonal zones in multiple sclerosis].

In a group of 31 patients with a confirmed diagnosis of multiple sclerosis the authors assessed the presence of oligoclonal abnormality of gammaglobulins in cerebrospinal fluid. Specimens of non-concentrated cerebrospinal fluid were examined by two separating methods which use as a vehicle polycryamide gel: isoelectric focusing and a modified electrophoretic technique. By isoelectric focusing an oligoclonal state was proved in 71%, the finding was doubtful in 16.