Lactobacillus reuteri alleviates diquat induced hepatic impairment and mitochondrial dysfunction via activation of the Nrf2 antioxidant system and suppression of NF-κB inflammatory response.

Accumulating evidence has shown that elevated oxidative stress and inflammatory response leads to hepatic impairment and dysfunction of hens during the aging process. This study was conducted to investigate the potential regulatory mechanisms of Lactobacillus reuteri (L. reuteri) in alleviating hepatic oxidative stress and dysfunction induced by diquat (DQ) exposure.

Theoretical study on the alkyl chain length impact of azobenzene-based photoresponsive ionic liquids.

The light-modulated isomerization and aggregation behavior of ionic liquids (ILs) in aqueous solutions holds fundamental and technological significance. Although several azobenzene-based photoresponsive ILs have been synthesized, there is still a lack of understanding regarding the aggregation mechanism, regularity of the alkyl chain length, and the position of the azobenzene (cis- and trans-) in these photoresponsive ILs. To elucidate the structure-property relationship of photoresponsive ILs, four types of azobenzene groups photosensitive ILs ([AzoCDMEA]Br, n = 2,4,6,10) in both trans- and cis- configurations were investigated by density functional theory (DFT) calculations.

Oxygen/siRNA-carrying fluoro-nanosensitizers for radio-immunotherapy sensitization.

The anti-tumor efficacy of radiotherapy (RT) is limited by the hypoxic and immunosuppressive tumor microenvironment (TME), which leads to RT resistance and failure in eradicating distant metastatic lesions. Herein, we developed a fluorinated nanosensitizer that could deliver both oxygen (O) and ADAR1 siRNA into tumor cells to reinforce RT by alleviating hypoxia and immunosuppression. Fluorinated poly(β-amino ester) (fPBAE) was designed to complex ADAR1 siRNA (siADAR1) via electrostatic attraction and load O due to the O-dissolving capacity of fluoroalkyls.

A quantitative solar ultraviolet radiation job-exposure matrix for Europe.

Introduction: Outdoor workers are exposed to high levels of solar ultraviolet radiation (UVR). UVR causes skin cancer and is a risk factor for cataract and other short- and long-term health effects, but there are significant knowledge gaps regarding the exposure-response relations based on quantitative measures of UVR exposure. We developed a quantitative UVR job-exposure matrix (JEM) for the general working population of Europe.

Antiviral treatment for viral pneumonia: current drugs and natural compounds.

In recent years, viral pneumonia has become a significant challenge to global public health, particularly during the COVID-19 pandemic. Viral pneumonia can be caused by various viruses, including influenza virus, RSV, and adenovirus. These viruses trigger inflammatory responses by invading the respiratory epithelial cells, leading to lung damage.