Publications by authors named "C L Galeotti"
Article Synopsis
- The human immune system continues to develop for several years after birth, affecting how young children respond to infections, such as SARS-CoV-2.
- Researchers studied T cell responses in children and adults before, during, and after SARS-CoV-2 infection, revealing that younger children (under 5) had a weaker CD4 T cell response compared to older children and adults with mild disease.
- Following infection, preschool-age children produced similar neutralizing antibodies to adults but had different T cell characteristics and fewer memory B cells, indicating a gradual maturation of their adaptive immune responses.
Article Synopsis
- Paediatric granulomatous uveitis (PGU) is a rare eye condition in kids that can cause serious problems with vision if not diagnosed early.
- The study looked at 50 young patients to understand the causes, treatments, and outcomes related to this condition.
- Most cases were either "idiopathic" (no known cause) or caused by sarcoidosis, and many kids experienced complications, so doctors often used treatments like corticosteroids and methotrexate.
MEVALONATE KINASE DEFICIENCY. Mevalonate kinase deficiency is a rare, autosomal recessive, auto- inflammatory disease, linked to mutations in the gene MVK, resulting in the activation of pyrin inflammasome and hypersecretion of interleukin-1β (IL-1β). The clinical spectrum realizes a continuum which extends from the mild phenotype of the partial MVK deficiency (hyperimmunoglobulinemia D) resulting in periodic fever syndrome to a letal form of mevalonate aciduria (MA, complete MVK deficiency).
View Article and Find Full Text PDFBackground: Pediatric Behçet's disease (PBD) is rarer than BD and can be a challenging diagnosis as clinical picture may be incomplete. As in adult patients, sight-threatening ocular manifestations may lead to diagnosis. In this study, we aimed to report a series of cases of PBD with ocular manifestations and provide a review of the literature.
View Article and Find Full Text PDFObjectives: Extra-osseous (EO) manifestations are poorly characterized in chronic recurrent multifocal osteomyelitis (CRMO). This study aimed to further define the frequency, characteristics and treatment of EO events in CRMO and whether different phenotypes can be distinguished and benefit from special management.
Methods: This multicentre retrospective study included CRMO patients followed in several paediatric rheumatology departments in France between 2015 and 2022.