Use of allopurinol to manage skewed 6-mercaptopurine metabolism in pediatric maintenance acute lymphoblastic leukemia treatment.

Background: 6-mercaptopurine is a cornerstone of maintenance therapy for pediatric ALL. Response to 6MP is typically determined by the ANC. Therapeutic ANC range while receiving 6MP is between 500 and 1500/μL.

Medication Desensitization: Single Intravenous Bag Method, in 3 Pediatric Patients.

Chemotherapies and biologic agents are known to cause hypersensitivity reactions (HSRs). It is imperative that pediatric patients receive these agents to treat their cancer or other rare condition, as oftentimes there are no available therapeutic alternatives. Successful medication desensitization has been described previously with a 12-step method using 3 intravenous (IV) infusion bags of varying concentrations.

Looking beyond person-specific cues indicative of credibility: Reward rules and executive function predict preschoolers' acceptance of (un)reliable assertions.

We tested whether 3- and 4-year-olds (N = 88) can deduce individuals' credibility exclusively from situational cues such as game rules that reward competitive or cooperative behavior-and whether children's inferences are predicted by their executive function (EF) and theory of mind (ToM) skills. When presented with the game rules, children endorsed a partner's claims more often if the rules incentivized cooperation between participants and partners (e.g.