Macromolecular Photoediting Using Single-Electron Logic.

Accessing the chemistry of reactive intermediates under mild conditions has significantly expanded the available chemical space for molecular transformations. Nowhere is this more apparent than in the context of photoredox catalysis. Despite abundant literature precedents for using this powerful methodology to build complex targets, there are comparatively few reports that leverage photoredox catalysis for macromolecular editing.

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.

The E3 ubiquitin ligase Pellino 1 (Peli1) is a microglia-specific mediator of autoimmune encephalomyelitis. Its role in neurotropic flavivirus infection is largely unknown. Here, we report that mice deficient in Peli1 (Peli1-/-) were more resistant to lethal West Nile virus (WNV) infection and exhibited reduced viral loads in tissues and attenuated brain inflammation.

Laser plasma x-ray source for ultrafast time-resolved x-ray absorption spectroscopy.

We describe a laser-driven x-ray plasma source designed for ultrafast x-ray absorption spectroscopy. The source is comprised of a 1 kHz, 20 W, femtosecond pulsed infrared laser and a water target. We present the x-ray spectra as a function of laser energy and pulse duration.

Very high laser-damage threshold of polymer-derived Si(B)CN-carbon nanotube composite coatings.

We study the laser irradiance behavior and resulting structural evolution of polymer-derived silicon-boron-carbonitride (Si(B)CN) functionalized multiwall carbon nanotube (MWCNT) composite spray coatings on copper substrate. We report a damage threshold value of 15 kWcm(-2) and an optical absorbance of 0.97 after irradiation.

Managing officer morale in 2012.

The stresses inherent in a hospital environment which impact on security may result in officers who do not see or feel positive results from the hard work they provide and, in experiencing low morale, can affect the performance of their peers, according to the author. In this article he describes what the healthcare security director can do to maintain high morale and, in doing so, retain the key members of his or her team.