Worsening disease severity as measured by I-SEE associates with decreased treatment response to topical steroids in eosinophilic esophagitis patients.

Background And Aims: The index of severity for eosinophilic esophagitis (I-SEE) grades eosinophilic esophagitis (EoE) severity across several domains. We assessed associations between EoE features and severity by I-SEE at diagnosis, and baseline I-SEE and outcomes following topical corticosteroids (tCS).

Methods: We conducted a retrospective cohort study of newly diagnosed EoE patients.

Effect of Monetary Incentives on Peer Review Acceptance and Completion: A Quasi-Randomized Interventional Trial.

Objectives: Peer review typically relies on experts volunteering their time to review research. This process presents challenges for journals that may face a shortage of qualified referees, resulting in either delay in handling papers or less thorough review than is optimal. We experimentally tested the impact of providing cash incentives to complete peer review assignments at Critical Care Medicine.

Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection.

Auxotrophic metabolic sensors (AMS) are microbial strains modified so that biomass formation correlates with the availability of specific metabolites. These sensors are essential for bioengineering (e.g.

Natural course of high-grade dysplasia in Barrett's esophagus: a scoping review and case-series.

Background And Aims: Endoscopic eradication therapy (EET) for Barrett's esophagus (BE) with high-grade dysplasia (HGD) aims to prevent progression to life-limiting cancer. However, HGD patients with a short life expectancy realize limited gains from this approach due to competing mortality. Clinicians are poorly equipped to counsel such patients, since little data describe survival in untreated HGD.

Histologic Response or Endoscopic Normalization After Initial Treatment for Eosinophilic Esophagitis in Children Leads to Less Fibrostenosis over Long-Term Follow-Up.

Background: Untreated eosinophilic esophagitis (EoE) can result in the development of fibrostenosis over time, but there are few data on whether successful treatment in childhood decreases this risk as children with EoE transition to adulthood.

Aim: To determine whether histologic response or endoscopic normalization after EoE treatment is associated with decreased development of fibrostenosis.

Methods: Pediatric subjects were identified from a large EoE database at an academic referral center.