Publications by authors named "C L Chio"
Enteric virus infection is a major public health issue worldwide. Enteric viruses have become epidemic infectious diseases in several countries. Enteric viruses primarily infect the gastrointestinal tract and complete their life cycle in intestinal epithelial cells.
View Article and Find Full Text PDFIn the eukaryotic cells, the ubiquitin-proteasome system (UPS) plays a crucial role in the intracellular protein turnover. It is involved in several cellular functions such as the control of the regular cell cycle progression, the immune surveillance, and the homeostasis. Within the 20S proteasome barrel-like structure, the catalytic subunits, β1, β2 and β5, are responsible for different proteolytic activities: caspase-like (C-L), trypsin-like (T-L) and chymotrypsin-like (ChT-L), respectively.
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- Mucoepidermoid carcinoma is a common malignancy in salivary glands, often linked to MAML2 gene rearrangement; primary cases in the nasopharynx are very rare.
- A 70-year-old man was found to have nasopharyngeal mucoepidermoid carcinoma, and MAML2 translocation was confirmed through a specialized test.
- Despite limited data, findings suggest that age and gender ratios in nasopharyngeal cases are similar to those in salivary glands, and most patients present with high-grade tumors, indicating a need for more research on MAML2's role in this cancer type.
Hydrogen sulfide (HS) is a crucial signaling molecule in plants. Recent studies have shown that HS plays an equally important role as nitric oxide (NO) and hydrogen peroxide (HO) in plant signaling. Previous studies have demonstrated the involvement of HS in regulating drought and other stressful environmental conditions, but the exact downstream molecular mechanisms activated by the HS signaling molecule remain unclear.
View Article and Find Full Text PDFBioactive compounds are abundant in animals originating from marine ecosystems. Ion channels, which include sodium, potassium, calcium, and chloride, together with their numerous variants and subtypes, are the primary molecular targets of the latter. Based on their cellular targets, these venom compounds show a range of potencies and selectivity and may have some therapeutic properties.
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