Pathology underrates colon cancer extranodal and nodal metastases; ex vivo radioimmunodetection helps staging.

Purpose: Colorectal carcinoma is frequently accompanied by small lymph nodes metastases that often escape pathologic examination. We evaluated whether ex vivo radioimmunodetection with the Affinity Enhancement System (AES) could improve detection of mesocolonic metastases.

Experimental Design: A bivalent 111In-labeled hapten was injected (16 patients) 4 days after a bispecific antibody (anticarcinoembryonic antigen, antihapten).

Hui and Walter's latent-class reference-free approach may be more useful in assessing agreement than diagnostic performance.

Background And Objective: Hui and Walter developed a latent class approach to assess the accuracy of a diagnostic procedure when no reference test is available. Our objective was to compare sensitivity and specificity estimates obtained with this reference-free approach and standard approaches, and to examine how and why they differed on a computerized tomography (CT) scan case study.

Study Design And Setting: We compared two sets of sensitivity and specificity estimates from four radiologists independently assessing tumoral and lymph node extension of 85 lung cancer patients with preoperative thoracic CT scan, those obtained relative to pathology findings from surgical specimens (reference set), and those derived from Hui and Walter's approach.

Comparison of digital and ultrasonographic examination of the cervix in predicting time interval from induction to delivery in women with a low Bishop score.

Objective: To compare pre-induction ultrasonographic cervical length and Bishop score in predicting time to delivery after labour induction with prostaglandins.

Design: Prognostic cohort study.

Setting: Tertiary referral maternity unit in a teaching hospital.

DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction.

Aim: To determine whether late recanalization of an occluded infarct artery after acute myocardial infarction is beneficial.

Methods And Results: Two hundred and twelve patients with a first Q-wave myocardial infarction (MI) and an occluded infarct vessel were enrolled. After coronary and left ventricular contrast angiography, patients were randomized to percutaneous revascularization (PTCA, n=109), carried out 2-15 days after symptom onset or medical therapy (n=103).

Interobserver and intraobserver reproducibility in the histopathology of follicular thyroid carcinoma.

We evaluated the interobserver and intraobserver reproducibility in the histopathology of follicular thyroid carcinoma (FTC). Forty-one anonymous FTC pathology slides were independently reviewed by 5 pathologists, and 31 of them were also evaluated twice by the same pathologist. A final consensus diagnosis (FCD) was made at the end of the study.