Publications by authors named "C L Burnard"

Article Synopsis
  • Heat stress triggers significant changes in gene expression, primarily involving the protein YTHDC1, which interacts with N-methyladenosine (mA) RNA modifications.
  • YTHDC1 relocates within the genome during heat stress, enhancing the expression of heat shock proteins (HSPs) and leading to altered transcript processing for many genes.
  • The study suggests that YTHDC1's accumulation in specific nuclear stress bodies helps regulate and time the overall gene expression response to heat stress.
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The development of protein and microorganism engineering have led to rising expectations of biotechnology in the design of emerging biomaterials, putatively of high interest to reduce our dependence on fossil carbon resources. In this way, cellulose, a renewable carbon based polysaccharide and derived products, displays unique properties used in many industrial applications. Although the functionalization of cellulose is common, it is however limited in terms of number and type of functions.

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Article Synopsis
  • MRN-MDC1 is critical for the DNA damage response (DDR) and repair, and it was found to associate with genes during transcriptional activation.
  • MDC1 interacts not only with DDR factors but also with proteins involved in gene expression and RNA processing, highlighting its multifaceted role.
  • The MRN complex (MRE11 and NBS1) is linked to actively transcribing genes and helps prevent DNA damage, indicating its role in maintaining the stability of genetic material during transcription.
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There is increasing interest in using nonblood measures of glucocorticoids to assess the physiological response to chronic stress conditions. In sheep, cortisol has been measured in various matrices including saliva, feces, and wool, but comprehensive studies of the relationship between plasma concentrations of cortisol and concentrations in these nonblood matrices are lacking. Therefore, we tested the hypothesis that administration of cortisol to sheep would result in elevated concentrations of cortisol in blood, saliva, feces, and wool.

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An understanding of the perceived importance of a variety of factors affecting the ease of handling of sheep and the interactions between these factors is valuable in improving profitability and welfare of the livestock. Many factors may contribute to animal behaviour during handling, and traditionally these factors have been assessed in isolation under experimental conditions. A human social component to this phenomenon also exists.

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