Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets. Here we describe ImmugenX, a modular protein language modelling approach to immunogenicity prediction for CD8+ reactive epitopes.
View Article and Find Full Text PDFJ Basic Clin Physiol Pharmacol
January 2024
Objective: The objective of our study was to assess the impact of heat stress on hydration and cognition among outdoor workers in hot environment.
Methods: Area heat stress assessments were measured using Quest Temp WBGT monitor. Sweat rate for dehydration and reaction time for acute cognitive processing were recorded using standard procedures.