Publications by authors named "C L Bjornson"
Objectives: Although croup is a common respiratory illness, there is little published regarding symptom course. We aimed to assess symptom progression and caregiver burden, and whether age, sex or season and initial severity of disease are associated with symptom duration.
Design, Setting And Participants: We conducted a secondary analysis of two Canadian prospective cohorts of children 0-16 years old diagnosed with croup; one recruited from a paediatric emergency department (ED) (307 children) between November 1999 and March 2000, and the other from 26 general EDs (1214 children) between September 2002 and April 2006.
Epidemiology and impact of methicillin-sensitive with β-lactam antibiotic inoculum effects in adults with cystic fibrosis.
Antimicrob Agents Chemother
December 2023
is the most prevalent cystic fibrosis (CF) pathogen. Several phenotypes are associated with worsened CF clinical outcomes including methicillin-resistance and small-colony-variants. The inoculum effect (IE) is characterized by reduced β-lactam susceptibility when assessed at high inoculum.
View Article and Find Full Text PDFEsophageal Atresia/Tracheoesophageal Atresia (EA/TEF) is a multisystem congenital anomaly. Historically, children with EA/TEF lack coordinated care. A multidisciplinary clinic was established in 2005 to provide coordinated care and improve access to outpatient care.
View Article and Find Full Text PDFArticle Synopsis
- Phasing of heterozygous alleles is essential for interpreting the effects of genetic variations related to cystic fibrosis (CF), and researchers sequenced 477 CF individuals to construct haplotypes using linked-read sequencing.
- The resulting haplotypes are visualized in an interactive web app called CFTbaRcodes, allowing for exploration of complex CF gene variations.
- Fine-mapping revealed that a specific 20-kb deletion and a missense variant are linked to an increased risk of CF-related meconium ileus and pancreatic issues, providing insights into the genetic mechanisms involved in both CF and non-CF pancreatitis.
Article Synopsis
- - Over 400 variants in the CFTR gene cause cystic fibrosis (CF), and while CFTR modulators can help improve lung function, they don't work for everyone and don't address all variants.
- - The study examines the SLC26A9 gene marker (rs7512462) and its relationship to lung function in CF patients before and after treatment, finding that certain genetic variants linked to SLC26A9 lead to better lung function and response to CFTR modulators.
- - The research suggests that targeting SLC26A9 could offer new therapeutic options not just for CF but also for individuals with other lung conditions like chronic obstructive pulmonary disease (COPD).