Publications by authors named "C L Beach"
Calcium channel blockers and beta blockers in pediatric supraventricular tachycardia.
J Cardiovasc Electrophysiol
November 2024
Introduction: Supraventricular tachycardia (SVT) is a common pediatric arrhythmia. Beta blockers (BBs) and calcium channel blockers (CCBs) are used for treatment despite little data examining their use. We describe the prescriptive tendencies, efficacy, and tolerability of BBs and CCBs used in the treatment of pediatric SVT.
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- ROS1 tyrosine kinase inhibitors (TKIs) are effective for treating ROS1-positive non-small cell lung cancer, but the emergence of resistance mutations, particularly L2086F, poses a challenge.
- The study compares the efficacy of different TKIs, revealing that type II TKIs maintain effectiveness against the L2086F mutation while type I TKIs do not, highlighting important structural differences in their binding.
- Results indicate that cabozantinib is effective against ROS1 L2086F in clinical cases, but its multi-kinase activity suggests the need for more targeted options, with gilteritinib offering potential benefits worth further exploration.